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How does the RAAS and the sympathetic nervous system activity contribute to an elevated blood pressure.
Step 1/1








Answer:-

By regulating pituitary hormone release, the sympathetic and parasympathetic nervous systems, and the baroreceptor reflex, the central nervous system regulates the circulatory system. More than two decades ago, immunoreactivity materials resembling digoxin and ouabain were discovered in the hypothalamic nuclei. These factors were thought to have an impact on blood pressure and electrolyte balance and appeared to be localized to the paraventricular and supraoptic nuclei, as well as the nerve fibers at the organs of the circumventricular. With more sodium consumed, the turnover rate of these materials increases. An endogenous digitalis-like factor (EDLF) was thought to regulate cardiovascular system-related functions in the brain, particularly after sodium loading, as ouabain injection increases blood pressure via sympathetic activation. Sympathetic Nervous System Essay Paper
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 	Explanation for step 1










The brain's ouabain mechanism of action involved sodium ions, epithelial sodium channels (ENaCs), and the renin–angiotensin–aldosterone system (RAAS), all of which are affected by sodium loading, according to experiments mostly conducted on rats. ENaCs are triggered by elevated sodium levels in the cerebrospinal fluid of rats fed a high-sodium diet. The RAAS is triggered in neurons by activated ENaCs and/or increased intracellular sodium; This causes the sympathetic nervous system to be triggered in the brain, releasing EDLF.









Final answer








The RAAS further activates the RAAS and increases sympathetic outflow in the brain by promoting oxidative stress. This cascade is activated in the brain by peripheral aldosterone and angiotensin II, resulting in increased sympathetic outflow and hypertension. As a result, the Na+–ENaC–RAAS–EDLF axis in the brain triggers sympathetic outflow and plays an important role in both primary and secondary hypertension. This report discusses the use of antihypertensive medications and provides an overview of the central mechanism underlying hypertension. Sympathetic Nervous System Essay Paper

Expert Answer

Question

How does the RAAS and the sympathetic nervous system activity contribute to an elevated blood pressure.
Step 1/1
Answer:-
By regulating pituitary hormone release, the sympathetic and parasympathetic nervous systems, and the baroreceptor reflex, the central nervous system regulates the circulatory system. More than two decades ago, immunoreactivity materials resembling digoxin and ouabain were discovered in the hypothalamic nuclei. These factors were thought to have an impact on blood pressure and electrolyte balance and appeared to be localized to the paraventricular and supraoptic nuclei, as well as the nerve fibers at the organs of the circumventricular. With more sodium consumed, the turnover rate of these materials increases. An endogenous digitalis-like factor (EDLF) was thought to regulate cardiovascular system-related functions in the brain, particularly after sodium loading, as ouabain injection increases blood pressure via sympathetic activation. Sympathetic Nervous System Essay Paper

ORDER A PLAGIARISM-FREE PAPER HERE

  • Explanation for step 1
The brain's ouabain mechanism of action involved sodium ions, epithelial sodium channels (ENaCs), and the renin–angiotensin–aldosterone system (RAAS), all of which are affected by sodium loading, according to experiments mostly conducted on rats. ENaCs are triggered by elevated sodium levels in the cerebrospinal fluid of rats fed a high-sodium diet. The RAAS is triggered in neurons by activated ENaCs and/or increased intracellular sodium; This causes the sympathetic nervous system to be triggered in the brain, releasing EDLF.
Final answer
The RAAS further activates the RAAS and increases sympathetic outflow in the brain by promoting oxidative stress. This cascade is activated in the brain by peripheral aldosterone and angiotensin II, resulting in increased sympathetic outflow and hypertension. As a result, the Na+–ENaC–RAAS–EDLF axis in the brain triggers sympathetic outflow and plays an important role in both primary and secondary hypertension. This report discusses the use of antihypertensive medications and provides an overview of the central mechanism underlying hypertension. Sympathetic Nervous System Essay Paper

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